@trevorflowers @chrishuck In aviation, safety-critical nuts and bolts are typically safety-wired or use cotter pins, with castellated nuts and/or drilled/safety bolts. There are often dissimilar metals in use with different rates of expansion, which I understand makes torque unreliable (I expect this is a substantial difference with the chemical plants).
Pairs of nuts or bolt heads are often safety-wired together with tight-wise winding (wrapped clockwise for right-handed threads) so that they protect each other from unwinding.
For cotter pins to lock nuts in place, bolts will have a hole (or, I think, sometimes a slot) for the cotter pin to go through a castellated nut and lock it in place.